I was at my wife's hometown for CNY and it seems her mother still does everything by hand. Pretty impressive... not sure how long I'd last doing that kind of hard labor. It does smell nice.
Yea that rice mill machine is similar to what I remember. Our village didn't have one so some guy would show up in harvest season to do it for every house in the village.
I can tell by the houses in your wife's village that their area was likely wealthier than ours growing up. Our houses looked more like this: https://imgur.com/a/Pc9LuKF
When I was a kid, it felt like there were only 2 or 3 villages total in my area since our parents didn't allow us to go too far. As a visiting adult, I found out that there were hundreds of similar villages in the region. Most of these villages are generally empty nowadays as people moved to cities. However, I heard from locals that some younger people are beginning to return to villages and raise their kids there.
I believe it's pretty quiet here too outside of CNY, although there is at least one active school nearby. Nice to hear some younger people are returning. It must be nice for kids to grow up in this kind of environment.
Oh I didn't realize that some people would interpret that machine as powered by electricity.
Our village didn't get electricity until the 90s, I think. I do remember having electricity growing up, and even a small TV. By the time I emigrated, some households had refrigerators.
> proposals to confiscate the assets of people not adopting the proponent's scheme (which immediately raises concerns about backdoors and consent)
They're going to lose those assets regardless, either to the first hacker with a QC or via a protocol-level burn. The latter is arguably better for the network's long-term health, as it reduces circulating supply rather than subsidizing an attacker.
I can understand disagreeing about timelines but is there a flaw in the logic that once the underlying crypto is broken, "consent" is a moot point?
You lost muscle because you lost around 1.54% of body weight per week, which is way too aggressive. The maximum recommended amount for losing weight while retaining muscle is around 1%. You will also most likely experience a weight rebound.
Hasn't this mostly been debunked? You lose muscle mass because you lost mass overall, and whether you lost it too quickly or not is not the major factor. AFAIK maintaining muscle mass while losing fat is borderline impossible for anyone who isn't extremely fat and/or very disproportionate composition to begin with.
Not at all, this is a well-known and long-established risk of rapid weight loss. Even long before any of these drugs existed, medical guidance was to lose weight slowly to help limit lean muscle loss.
Not as far as I know. The ratio of fat-to-muscle loss depends on several factors, most notably the rate of weight loss (see https://pubmed.ncbi.nlm.nih.gov/34371981/). In fact, retatrutide is popular notably because it is known to preserve lean body mass better than other weight loss drugs.
Seems you are correct according to https://pubmed.ncbi.nlm.nih.gov/40609566/: "The proportion of lean mass loss to weight loss was similar to other obesity treatments."
You need to define how much muscle mass you expect to lose. The entire idea behind the bulk/cut cycle is that you want to net gain muscle after a full diet cycle.
It's also not borderline impossible to maintain the majority of your muscle mass, but it depends on how you eat and train. We don't know enough about the person above's diet, training, current body composition, etc. to say anything for certain.
The author is missing a massive segment of that gray market: people who buy FDA-approved weight loss drugs (e.g., semaglutide or tirzepatide) at 2–5% of the brand-name price. This route carries some risk, but there are ways to mitigate it, such as performing third-party testing. I assume most people who do this couldn't realistically afford the brand-name drug anyway, making this their only viable treatment.
Even if you test a batch once, do people who get testing done do testing on all batches?
The synthesis of peptides uses some NASTY chemicals. I would be worried about lax manufacturer policies leading to contamination, even if one batch passes. The costs of FDA certification are the effect of that protection.
But whatever, this is the same attitude that people have against owning insurance. It is hard to recognize the cost of risk.
Won't be anywhere near that. I don't have prices handy, but Lilly sells tirzepatide (a bit better than sema, and usually a bit more expensive) at 500/mo (maybe a bit less now on the trump rx site, I don't recall). Depending on dose, that'll be about 10 bucks a mg give or take. At 50c/mg for sema you were paying a bit of a premium. These days even tirz is only about 30-35c/mg.
I used to buy from Peptide Sciences so I was certainly paying a premium for reputation at $20/mg. I think Semaglutide is now at a bit of a premium due to it falling out of favour and most people switching to Triz and Reta. I only take a low dose and am happy to stick with what's working.
There must be an irony that it was Trumps crackdown on peptides, I presume to prop up his prescription company, that forced me to switch to Chinese supply. By doing it all at once it created a critical mass for that market.
IIRC the biggest impetus for cracking down was Lilly throwing a fit about the gray market supplying reta well before it even becomes available via the normal channels (who knows when that will be). But as you say, it just pushes people to buy direct from Chinese vendors (and it is basically impossible to stop direct imports like that). Would be safer if more reputable US-based sellers could supply it semi-openly as before. Nexaph is still selling it, but I figure the clock is ticking on that.
> and it is basically impossible to stop direct imports like that
How so? Is there a particular characteristic of the US that makes it so, or of the channels through which this is done? I get that in general it's impossible as with recreational drugs, but when you look at cocaine then at least to traffick it to most wealthy countries it takes a large amount of resources and is at high risk of getting caught. Which is why they're increasingly starting to use narco submarines. This greatly increases the price of the product. Why can't the same happen to peptide imports?
The US is a rather dysfunctional country along many axis and an inability to stop imports is one of them. The difference between drugs and peptides is that by weight peptides are much more valuable. 1kg of cocaine is $28K, fentanyl is $150K, and semaglutide is $500K.
High-Performance Liquid Chromatography so purity and concentration.
Back when I started few people were doing this and it was more of a risk, I was buying from research peptide vendors who had their own testing practices, but now a huge number of people are doing it and there are markets where reputations matter and it appears to be reasonably efficient.
I would prefer not to inject peptides from gray market China but practically all of the gray/black market supply is from there. I will likely switch to pharma grade when generics become available.
Im a libertarian at heart so cant argue too much with people's personal choices, but I can only say that given what I know can go wrong in even the best maintained lab, I wouldn't ever do what youre doing. Yes its all great today, but the day something goes wrong, you may not be happy finding out how its affecting you. Look up the bayer factor viii hiv incident.
Last I checked, Ozempic (Semaglutide) is around $1000/month in the US. A typical 1 month pen is 4-8mg, so around $250/mg to $500/mg. So yeah, I may have understated how much cheaper the gray market version is.
Novo Nordisk's drugs can be had as low as $250/month through third party (which is weird), though they'll probably honor those prices in direct sales before long.
I imagine it's legally risky to buy a large quantity, test it, and then resell smaller quantities. That's a shame because the alternative is probably that some folks settle for products of dubious quality and end up getting hurt.
Yes, I believe most people buy directly from somewhat shady Chinese factories. I tried contacting a few and they all refuse to meet or send samples from within China, so I assume what they're doing is illegal in China. In the US, it's legal to sell them as a "research chemical" but the FDA is cracking down on companies that are clearly engaging in b2c.
Right, but I don't know the people at those companies. I have local chemists that I trust. I'm just lamenting the fact that developing that kind of trust network everywhere, so everybody can be similarly sure of what they're putting in their body, is likely to run afoul of local laws.
FWIW, finnrick's claim to fame is being free. Someone is paying for it. They have also failed blind tests in the past, Janoshik (IIRC) never has. There are several US-based labs but none of them have the same reputation as Janoshik.
Actually, you just described most of the tele-health and compounding pharmacies that carry GLP1s!
Where do you think Hims, Ro, Brello, or the rest get the APIs they sell to their customers? They get them from grey market suppliers in China. They don't go to Ely Lilly or NovoNordisk and say, "politely sir, may I skirt around your IP and sell your drugs for 10x what they cost instead of 10,000x what they cost?" Hopefully, they test them and filter them and use sterile/pharma processes for what they sell to their customers. Well, except for the Medspas, those are just wild west snake oil farms.
We need to change the law so that the crime is selling mislabeled or contaminated drugs. If you can cook it well enough in your kitchen, you should be allowed to share it with a neighbor in need.
Things have changed a little, but during the time that compounding was explicitly allowed, the licensed pharmacies were buying from FDA approved manufacturers, sometimes in China, and sometimes the same manufacturers who also do contract manufacturing for Lilly.
Today ... who knows? It might just be the same gray market stuff us plebes can get.
It probably is, but that does not stop people from effectively doing it. There are a number of groups that specialize in conducting group buys, doing a bunch of testing on randomized samples, and then shipping out the product to individuals.
Also, if you plan to be on it a good long time, you can buy a bunch of kits yourself (a kit is 10 vials), run a bunch of tests, and then just have a nice stockpile that will last you years. The testing will likely cost as much or more than the product itself, but given how inexpensive the product is, you still come out way ahead financially.
>I imagine it's legally risky to buy a large quantity, test it, and then resell smaller quantities
It is illegal, but it doesn't stop people from doing it. In fact, if you don't have any sort of test results for your peptides people will absolutely avoid buying your wares until you have them. Purity and mg/ml are the 2 basic test results that any shop worth their stuff will have.
To be fair, most everyone I know who is buying on the gray market considers vendor tests to be minimally required, but still insufficient -- there is no assurance they tested the product they shipped to you. Plan on testing it yourself. I'm sure some people do trust nexaph enough, though, to not worry so much. Whether that trust is well placed, that is a separate discussion.
With most of these you can really tell if they work or not and there is a pretty predicable dose dependent reaction profile. With slow meds like semaglutide you'd maybe not notice it in the first week but you will by week 3. I had mine tested but if that wasn't available I probably would have considered the anecdotal evidence to be sufficient. It appears that most of the scamming is just people taking the money and not shipping anything.
The most dangerous failures I've seen have been sending the wrong peptide. 15 mg of tirzepatide and 15 mg of semaglutide is a very different experience.
After nearly getting hosed in a group buy (I did get refunded, but that is far from a guarantee) because of a product mismatch, I decided to just pay for nexaph. Love him or hate him, his popularity relies on his reputation and he has been more careful than most suppliers to cultivate it with more extensive testing and quality control.
That makes sense, I don't like that the bottles are unlabelled so the first thing I have to do is label them. The box is labelled and this seems to be standard practice. Semaglutide is falling out of favour so I guess they're substituting. I have 4 years supply now so I guess I'll check back then and see where the market is at.
I know a bunch of people with multi-year stockpiles. I've got ~5 years of reta and ~6 years of tirz. This is too much, of course, but I determined a while back that under no circumstances do I ever intend to find myself unable to source it. My life is immeasurably better after losing 110 pounds.
Could you direct me to some resources you used to figure out dosing and sourcing? I’ve been interested in trying it out (need to lose a lot of weight) but have been paralyzed by too much contradictory information.
While I agree with you, I also find myself wondering who draws the line. Given the current political atmosphere and its increasingly fluid relationship with "truth," I have to consider that the line for others may not be where it is for me — especially given the nuance buried in the details of many B2B deals.
Their value prop had to be strong enough to get past YC, past the other founders in the batch, past due diligence. Given that, I'm no longer comfortable casting "fraud" as a clean binary.
To be clear — I do genuinely believe they are a fraudulent company that lied and deserved to be removed. But introspectively, I have to sit with the fact that the space between "working around dumb regulations" and "outright fraud" is murkier than we'd like to admit.
The vast majority of crimes are still being prosecuted as such. You have to reach a certain size/notoriety and money to buy a POTUS pardon; I doubt that matters for a relatively unknown outfit like Delve.
3. Customers want to do something, you help them do it, and nobody has done it before, so whether it's legal or not is kind of up in the air.
E.G. Uber exploited a legal loophole that distinguished the kind of taxi service you hail on the street from the kind of taxi service you call on a phone.
The latter were much less regulated, and usually much more exclusive and pandering to a richer crowd. Nobody really knew which kind Uber should be classified as, it was the first kind in practice (same customer base as normal taxis) but the second in theory (ordered, not hailed).
It is clearly different because in one case you are not guilty of fraud.
Being guilty of a crime plus fraud is obviously worse than just being guilty of the crime.
Breaking the law by stealing a loaf of bread is obviously different to killing one million people but "both boil down to breaking the law" - I'm not sure that comment contains that much information.
They should charge a small annual fee and let people reserve a custom word for a given IP. You could even have a small utility on your computer that automatically queries given names to "resolve" to IPs.
And then if they don't like someone they should revoke their word. And they should make it so words with certain endings are delegated to other countries who can also revoke your word if they don't like you.
To facilitate client to client communications, they should add a who-does-it-serve (short WHO DIS) system to get contact information of already reserved names.
I'm surprised that they don't just keep the various prompts, which are arguably their "secret sauce", hidden server side. Almost like their backend and frontend engineers don't talk to each other.
My company uses Claude through our own private data centers behind our own proxy that logs all requests and responses in and out. However, Anthropic heavily steers these models during RL to respond a certain way to certain prompting, so that's basically the "secret sauce" you're thinking of.
i always wondered what prompts codex / claude code use but always figured they just send variables to the backend and render the whole prompt there so i never even bothered to check with a MITM proxy. turns out i should have just done that…
Coincidentally, that's where I ate my first insects as a kid. I was fond of the chocolate covered grasshoppers. The museum also had an impressive butterfly collection.
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