Federal courts were striking down state laws for violating the federal constitution while the founders were still politically active; most notably for intruding on Congress's Commerce clause authority.
They might have been disquieted by the kind of restrictions on the state that emerged later based on the civil war amendments, especially the 14th, but then, many modern Americans would be disquieted by the founders acceptance of slavery while speaking of equality popular sovereignty.
The founders weren't gods, but men taking some controversial--even among each other--steps forward for the political context of their day.
They might have been disquieted by the kind of restrictions on the state that emerged later based on the civil war amendments, especially the 14th, but then, many modern Americans would be disquieted by the founders acceptance of slavery while speaking of equality popular sovereignty.
The founders weren't gods, but men taking some controversial--even among each other--steps forward for the political context of their day.